TB-500
Most human data come from full-length thymosin ฮฒ4 programs; the TB-500 fragment itself is studied largely in preclinical models.
Thymosin Beta-4 and TB-500 in Tissue Healing, Regeneration, and Musculoskeletal Repair: A Scoping Review
This scoping review screened 1,772 records and synthesised 80 studies on thymosin ฮฒ4 and the TB-500 fragment, reporting that the tissue-healing literature is concentrated in wound/skin, vascular, ocular and bone categories and remains predominantly preclinical.
View study โRecombinant human thymosin ฮฒ4 improves ischemic cardiac dysfunction in mice and patients with acute STEMI after reperfusion
The authors reported that recombinant human thymosin ฮฒ4 reduced cardiac dysfunction and fibrosis in mouse ischemia/reperfusion models, and in an accompanying randomized trial of 96 STEMI patients observed reduced infarct size only in the subgroup treated within 8 hours of PCI.
View study โThe combined impact of thymosin ฮฒ4 and selenium on diabetic ulcers: a comprehensive review
This narrative review summarised preclinical evidence that thymosin ฮฒ4 promotes re-epithelialization and angiogenesis in wound models and discussed, at a research level, its proposed combination with selenium in diabetic-ulcer contexts.
View study โThymosin ฮฒ4 denotes new directions towards developing prosperous anti-aging regenerative therapies
Using cardiac tissue as a model, the authors reviewed evidence that thymosin ฮฒ4 is developmentally expressed and, in adult post-infarction animal models, was associated with improved myocyte survival and cardiac function.
View study โ0.1% RGN-259 (Thymosin ฮฒ4) Ophthalmic Solution in Neurotrophic Keratopathy: a Phase III Randomized Trial
In this double-masked Phase III trial of the thymosin ฮฒ4 ophthalmic solution RGN-259 for neurotrophic keratopathy, the authors reported complete corneal healing at 4 weeks in 6 of 10 treated versus 1 of 8 placebo subjects, with improvements in ocular comfort and no significant adverse effects.
View study โProvided for educational and reference purposes only. These materials are sold strictly for laboratory research and are not for human or animal use.